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A Comparison of Growth Potentialities of Human Tumors in Tissue Culture and on Heterologous Transplantation^*

Wilhelm S. Albrink and A. Cameron Wallace

( Department of Pathology, Yale University School of Medicine, New Haven, Conn.)

Thirty-three human tumors, either malignant or suspected of malignancy, were explanted to Carrel flasks with chicken plasma clots and were transplanted to the eyes and/or brains of heterologous species. Growth of recognizable tumor cells in tissue culture resulted with all fourteen tumors of mesenchymal or neurogenic origin. Growth occurred in nine of nineteen cultures of carcinomas. Of the ten carcinomas failing to show growth of tumor cells, seven were adenocarcinomas of the breast. There was no correlation between growth in tissue culture as compared to growth on heterologous transplantation on the one hand or the survival of the patient on the other.

^* Aided by grants from the Jane Coffin Childs Memorial Fund for Medical Research and the David, Josephine & Winfield Baird Foundation, Inc.

Present address: Dept. of Medical Research, University of Western Ontario, London, Ontario, Canada.

Received 10/18/52.