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Non-utilization of Radioactive Iodinated Uracil, Uridine, and Orotic Acid by Animal Tissues in Vivo^*

W. H. Prusoff, W. L. Holmes and A. D. Welch

Department of Pharmacology, School of Medicine, Western Reserve University, Cleveland, Ohio)

Iodouridine, iodoorotic acid, and iodouracil, labeled with I¹³¹, were synthesized. The syntheses of iodouridine and iodoorotic acid have not been described previously. The incorporation of these three I¹³¹-labeled pyrimidines into normal tissue, regenerating liver, and experimental tumors was investigated, and no significant preferential concentration was observed.

^* This investigation was supported, in part, by a grant from the National Institutes of Health, U.S. Public Health Service.

Merck Postdoctoral Fellow of the National Research Council of Canada.

Received 9/22/52.

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