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The Interaction of Carcinogenic Hydrocarbons with Tissue Constituents

II. 1,2,5,6-Dibenzanthracene-9,10-C¹⁴ in Skin^{* ,}

Walter G. Wiest and Charles Heidelberger

( McArdle Memorial Laboratory, Medical School, University of Wisconsin, Madison 6, Wis.)

The irreversible chemical binding of 1,2,5,6-dibenzanthracene-9,10-C¹⁴ to the proteins of a skin fraction containing epidermis and part of the dermis has been demonstrated. The variation of specific activity of the protein with time after application has been determined. The binding occurs only in vivo and is not due to surface adsorption. The binding occurs between the carcinogen or its metabolite and the nucleoproteins, particulate and soluble proteins, but not with nucleic acids. The possible significance of this phenomenon in the carcinogenic process is discussed.

^* An abstract of this report appeared in Cancer Research, 12:308, 1952.

This work was supported by a grant from the Wisconsin Section of the American Cancer Society, by a grant-in-aid from the National Cancer Institute, and by the Pearl and W. M. Quandt Memorial Fund.

Present address: Department of Biochemistry, University of Utah Medical School, Salt Lake City, Utah.

Received 10/20/52.

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