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The Interaction of Carcinogenic Hydrocarbons with Tissue Constituents

III. 1,2,5,6-Dibenzanthracene-9,10-C¹⁴ in the Submaxillary Gland^{* ,}

Walter G. Wiest and Charles Heidelberger

( McArdle Memorial Laboratory, The Medical School, University of Wisconsin, Madison 6, Wis.)

The distribution of radioactivity following the direct administration of 1,2,5,6-dibenzanthracene-9,10-C¹⁴ into the submaxillary glands of mice has been studied. Tricaprylin and sucrose were used as the vehicles of injection. The distribution of total radioactivity depended on the vehicle. The presence of protein-bound radioactivity in all cell fractions of the gland was established. Only the C¹⁴ in the soluble protein fraction showed significant changes with time. The binding occurred with nucleoprotein, but not with nucleic acids. This binding could be obtained in vitro. The possible significance of these findings in relationship to the process of carcinogenesis has been discussed.

^* An abstract of this report appeared in Cancer Research, 12:308, 1952.

This work was supported by a grant from the Wisconsin Section of the American Cancer Society, by a grant-in-aid from the National Cancer Institute, and by the Pearl and W. M. Quandt Memorial Fund.

Present address: Department of Biochemistry, University of Utah Medical School, Salt Lake City, Utah.

Received 10/20/52.