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Obesity and the Time of Appearance of Spontaneous Mammary Carcinoma in C3H Mice^*

( Department of Pharmacology and Therapeutics, Stanford University School of Medicine, San Francisco, and the Laboratory of Experimental Oncology, Public Health Service, University of California School of Medicine, San Francisco, Calif.)

1. Virgin C3H female mice made obese experimentally with toxic doses of gold thioglucose show an earlier appearance of spontaneous mammary carcinomas than do control mice of normal weights.

2. The average time of appearance of spontaneous tumors in the obese mice was 246 days, compared to 303 days in the nonobese mice.

3. Animals injected with gold which did not become obese showed the same time of appearance of tumors as did the untreated mice.

^* This investigation was supported by a grant-in-aid from the National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md.

Received 11/ 3/52.

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