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The Influence of 8-Azaguanine on the Mitotic Rate and Histological Appearance of Certain Normal and Neoplastic Tissues^*

( Zoological Laboratory, University of Massachusetts and Biological Laboratory, Amherst College, Amherst, Mass.)

1. 8-Azaguanine caused a decrease in the mitotic rates of carcinomas 755 and E 0771 in mice.

2. The mitotic rates of mouse tumors C 954, C 1300, S 91, and S 180 were unaffected by the drug.

3. 8-Azaguanine did not change the mitotic rates of jejunum, ileum, or testis in mice bearing any of the six tumors studied.

4. Cell size remained the same in treated and control tumors whether or not the tumor was inhibited by 8-azaguanine.

5. One of the tumors studied, 755, developed an increased amount of fibrosis under the influence of 8-azaguanine.

6. With tumors 755 and E 0771, colchicine counts of mitoses in livers of tumor-bearing and nontumor-bearing mice (all untreated) revealed no differences between the two groups.

^* This investigation was supported in part by a grant from Research Corporation and in part by a grant (C-1661) from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 11/10/52.