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Fungi in Human Neoplastic Tissue^*

Herbert Mescon, John W. Eiman and Albert M. Kligman

( Department of Dermatology [Donald M. Pillsbury, Director], and the Department of Surgical Pathology [Robert C. Horn, Jr., Director], Hospital of the University of Pennsylvania, Philadelphia, Pa.)

1. Sixty-three benign and malignant tumors were cultured for fungi. Twenty-three specimens revealed no growth. From the other 40 specimens, sixteen different organisms were isolated. No one species of fungus was isolated in more than 15 per cent of the positive sepcimens.

2. Two hundred and fifty-five specimens, including malignant and benign tumors, 28 cases of sarcoid and a number of miscellaneous non-neoplastic lesions, were examined by the Hotchkiss-McManus technic. No fungi were observed, except in one section from a case of sarcoidosis. Other sections from this same block of tissue failed to reveal fungi by staining.

3. It is concluded that the fungi isolated from human neoplasms were probably chance contaminants.

^* This work was done in part under a Damon Runyon Clinical Research Fellowship on recommendation by the Committee on Growth of the National Research Council and administered by the American Cancer Society, Inc.

Present address: Department of Dermatology, Boston University, School of Medicine.

Received 9/24/51.