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Cytological Studies on the Ehrlich Ascites Tumor before and after Infection with Bunyamwera Virus^*

( Viral and Rickettsial Research, Lederle Laboratories Division, American Cyanamid Company, Pearl River, N.Y.)

1. Several features of the morphology and cytochemistry of the Ehrlich ascites tumor cell have been analyzed.

2. The occurrence of nuclear budding or amitotic nuclear division and the development of acidophil intranuclear bodies from the nuclear parachromatin have been described. These bodies are only rarely observed in the uninfected tumor cells, and they have been shown to be chemically and functionally related to nucleoli; it is proposed to call them pseudonucleoli or parachromatin bodies.

3. Bunyamwera virus infection of the Ehrlich ascites tumor results in a selective destruction of the tumor cells. The destructive process involves the intermitotic phase of the cell; it is characterized by the development of prominent pseudonucleoli in a large proportion of infected cells and by the occurrence of multiple nuclear budding similar to, but more pronounced than, that which is occasionally observed in the uninfected tumor cell.

^* A preliminary report of this work was presented at the 37th Annual Meeting of the American Society for Experimental Pathology in New York City, April 15, 1952 (Fed. Proc., 11:421, 1952).

Received 11/28/52.