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A Decrease in Plasma Sulfhydryl Content in the Dog after Intravenous Administration of 3,4-Benzpyrene^{* ,}

( Department of Biochemistry, University of Tennessee, Memphis, Tenn.)

Intravenous injections of aqueous colloidal dispersions of 3,4-benzpyrene produced in rabbits and dogs a significant decrease of serum or plasma sulfhydryl content which persisted for a considerable period of time after removal of the benzpyrene colloid from active circulation. This effect was not produced by molecularly equivalent amounts of anthracene administered in the same manner.

^* This investigation was supported by research grants from the National Cancer Institute of the National Institutes of Health, Public Health Service, and from the American Cancer Society.

A preliminary report of these studies was presented at the Southwide Chemical Conference of the American Society, Wilson Dam, Alabama, October, 1951.

Received 12/ 1/52.