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Metabolism of Neoplastic Tissue. V. Fatty Acid Oxidation in Slices of Transplanted Tumors^*

Sidney Weinhouse, Arthur Allen and Ruth H. Millington

( Lankenau Hospital Research Institute and Institute for Cancer Research, and Department of Chemistry, Temple University, Philadelphia, Pa.)

Slices of transplanted mouse and rat tumors oxidized C¹⁴-labeled long- and short-chain fatty acids to CO₂, though at rates generally lower than liver slices. Differences between liver and tumor slices were greater with the short-chain fatty acids, and these differences could be at least partly attributed to a greater inhibitory action of the shortchain acid on the tumor cells.

Fatty acid oxidation in tumors, including hepatoma, resembled that of nonhepatic tissues in that it was not associated with ketogenesis. Tumor slices, including hepatoma, also resembled nonhepatic tissue in having a high capacity for acetoacetate oxidation.

^* This study has been aided by grants from the National Science Foundation; the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service; the American Cancer Society, on recommendation of the Committee on Growth of the National Research Council; and the Atomic Energy Commission (Contract No. AT(30-1)777).

This work is taken from a thesis by Arthur Allen to be presented to the Graduate School of Temple University in partial fulfilment of the requirements for the M.A. degree.

Received 12/ 5/52.