This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Duran-Reynals, F. Articles by Freire, P. M. Search for Related Content PubMed Articles by Duran-Reynals, F. Articles by Freire, P. M.

The Age of the Tumor-bearing Hosts as a Factor Conditioning the Transmissibility of the Rous Sarcoma by Filtrates and Cells^{* ,}

( Department of Microbiology, Yale University School of Medicine, New Haven, Conn.)

The filtrability of the Rous sarcoma is inversely related to the age of the hosts and age of the tumors. Also, the tumors induced by cell suspensions have a higher filtrability than those induced by filtrates.

The transmissibility of the tumors by cells is inversely related to the age of tumors and, under certain conditions, directly related to their filtrability.

The occurrence of metastases is directly related to the filtrability of the tumors and to their transmissibility by cells.

Virus can be recovered from the nonfiltrable tumors by passage of the sarcoma cells into other hosts.

The findings are discussed in relation to the effect of the age factor on the tumor and its causative virus.

^* This investigation was aided by research grants from the Jane Coffin Childs Memorial Fund for Medical Research, the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service, and the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

The experimental material of this paper has been included in a dissertation presented by the junior author to the Faculty of Yale University School of Medicine, in partial fulfilment of the requirements for the degree of Doctor of Public Health.

Received 12/22/52.