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The Development of Metastases from the Rous Sarcoma in Relation to Some Characteristics of Its Causative Virus^{* ,}

P. M. Freire, F. Duran-Reynals and Estelle Bryan

( Department of Microbiology, Yale University School of Medicine, New Haren, Conn.)

The incidence of metastases from the Rous sarcoma in hosts inoculated in a given passage with filtrates and cells of the sarcoma was significantly decreased with an increase in the age of the tumors of the preceding generation from which the injected materials were obtained.

The finding is discussed in relation to the depressing action of the age factor on properties of the tumors through an effect on the causative virus.

^* This investigation was aided by research grants from the Jane Coffin Childs Memorial Fund for Medical Research, the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service, and the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

The experimental material of this paper has been included in a dissertation presented by the senior author to the Faculty of Yale University School of Medicine, in partial fulfillment of the requirements for the degree of Doctor of Public Health.

On leave from the Department of Health of the State of São Paulo, Brazil. Present address: Instituto Biológico, Caixa Postal 7119, São Paulo, Brazil.

Received 12/22/52.