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The Metabolism of Benzidine in the Rat

( Clayton Aniline Company Ltd., Clayton, Manchester 11, England)

The distribution of benzidine, expressed as diazotizable amino groups following a single intraperitoneal injection, has been studied in the rat.

The aromatic amino groups were present in both the "free" and conjugated form, the latter amounting to 24 or 49 per cent of the dose after 4 or 12 hours.

By 12 hours, a portion of the injected amino groups are rendered nondiazotizable, since only 68 per cent could be accounted for at this time, as compared to 93 per cent 4 hours after injection.

It is suggested, in the light of the similarity of benzidine and 2-aminofluorene metabolism, that this difference in recovery may be due, in part, to in vivo oxidation.

Received 3/ 3/53.