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Systemic Effects of Tumors in Force-fed Rats

II. Effect on the Weight of Carcass, Adrenals, Thymus, Liver, and Spleen^{* ,}

A. G. Stewart and R. W. Begg

( Department of Medical Research, University of Western Ontario, London, Canada)

Force-feeding high fat, carbohydrate, and protein diets to rats bearing the Walker 256 carcinoma greatly reduced, but did not prevent, the loss of carcass weight noted in tumor-bearing rats fed ad libitum.

Maintenance of the food intake did not alter the enlargement of liver and spleen that occurs in tumor-bearing rats fed ad libitum, but some increase in adrenal enlargement and thymus involution was observed, presumably owing to the stress of force-feeding.

^* Supported by a grant from the National Cancer Institute of Canada. A preliminary report of this work was presented to the Royal Society of Canada in Montreal, June, 1951.

The work reported was taken from a thesis submitted by A. G. Stewart for the degree of Doctor of Philosophy at the University of Western Ontario.

Present address: Department of Biochemistry, University of Alberta, Edmonton, Alberta.

Research associate, National Cancer Institute of Canada

Received 12/16/53.

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