This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stewart, A. G. Articles by Begg, R. W. Search for Related Content PubMed PubMed Citation Articles by Stewart, A. G. Articles by Begg, R. W.

Systemic Effects of Tumors in Force-fed Rats

III. Effect on the Composition of the Carcass and Liver and on the Plasma Lipids^{* ,}

A. G. Stewart and R. W. Begg

( Department of Medical Research, University of Western Ontario, London, Canada)

The effects of the Walker 256 carcinoma have been studied in male rats force-fed high fat, carbohydrate, and protein diets until the tumor attained a size of approximately 20 per cent of the body weight.

The loss of nitrogen and fatty acids from the carcasses of tumor-bearing rats was diminished but not prevented by forced feeding.

The total lipid content of the plasma was variable and reached very high values in tumor-bearing rats fed high fat diets. Increases in phospholipid and total cholesterol accounted for only a small fraction of the increase, which is presumably owing to neutral fat.

The nitrogen, total lipid, and phospholipid contents of the livers of tumor-bcarcrs were similar to those of control rats.

^* Supported by a grant from the National Cancer Institute of Canada. An abstract has been published in Cancer Research, 12:300, 1952.

The work reported was taken from a thesis submitted by A. G. Stewart for the degree of Doctor of Philosophy at the University of Western Ontario.

Present address: Department of Biochemistry, University of Alberta, Edmonton, Alberta.

Research Associate, National Cancer Institute of Canada.

Received 12/16/53.

This article has been cited by other articles:

				S. Holmes Nutrition in the Cancer Patient The Journal of the Royal Society for the Promotion of Health, August 1, 1987; 107(4): 124 - 127.