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Attempts To Induce Immunity against Mammary Adenocarcinoma in Inbred Mice

( Biological Laboratories, Schering Corporation, Bloomfield, N.J.)

Experiments are described in which attempts were made to induce immunity in C3H/He and in ZBC mice by strangulation of implanted strain-specific mammary carcinoma. C3H/He mice in which tumors were thus destroyed were not immune upon reimplantation with adenocarcinoma C3H-BA, nor with two other spontaneous mammary tumors which arose in this strain. Similarly, ZBC mice were not immune upon reimplantation with a mammary tumor which arose in the Z strain, nor were C57Bl/6 mice immune to reimplantation of adenocarcinoma E 0771.

Induced autolysis and destruction of these strain-specific mammary adenocarcinomas growing in mice of the strain in which they arose spontaneously does not lead to immunity against the same strain-specific tumor.

Received 2/ 9/53.