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Tissue Culture Screening of Amino Acid Analogs for Selective Damage to Mouse Sarcoma Cells^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, N.Y.)

1. Comparative toxicities in tissue cultures of mouse heart and of sarcoma T-241 are reported for 50 amino acid analogs.

2. Although highly toxic compounds were found in this group, high selective toxicities to sarcoma T-241 were rare.

3. Of a group of halogenated phenylalanines, only the fluorophenylalanines were competitive antagonists of L-phenylalanine, but the effect of the position of substitution on the differential toxicity was similar for the chloro- and bromo-phenylalanines.

4. Ethionine showed a fairly high selective toxicity to sarcoma T-241. Its toxicity was not blocked by methionine or choline. Methionine gave about the same toxicity picture as did ethionine.

^* This work was supported by grants from the American Cancer Society; the Damon Runyon Memorial Fund for Cancer Research; and the National Cancer Institute, National Institutes of Health, Public Health Service.

Received 3/30/53.