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Morphologic and Biologic Changes in a Mouse Ascites Tumor Following Induced Infection with Certain Viruses^*

( Papanicolaou's Cytology Laboratory, Department of Anatomy, Cornell University Medical College, New York City, and Viral and Rickettsial Research, Lederle Laboratories Division, American Cyanamid Company, Pearl River, N.Y.)

Studies have been made on the effect of the following twelve viruses upon the Ehrlich ascites tumor: Bunyamwera, eastern and western equine encephalomyelitis, GDVII strain of mouse encephalomyelitis, Ilheus, influenza A (neurotropic WS strain), Japanese B encephalitis, louping-ill, rabies, Semliki forest, St. Louis encephalitis, and West Nile (M 956 and Egypt 101 strains).

By morphologic and biologic criteria, Bunyamwera virus was found to display a powerful inhibitory effect upon the growth of the malignant cells. West Nile virus also interfered with the tumor growth, as indicated by the results of bioassay. Eastern and western encephalomyelitis, Semliki forest, and rabies viruses usually failed to multiply in the ascites tumor, and they had no effect on the viability of the tumor cells. The other six viruses did multiply in the ascites tumor, and their effect on the viability of the tumor cells was either negligible or equivocal. These findings are discussed briefly in the light of the usefulness of the ascites tumor as a medium for viral growth.

^* This project was supported in part by a Control Project Grant to the Papanicolaou Cytology Laboratory from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

Received 4/27/53.