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The Effect of Antibiotics upon the Growth of Sarcoma 180 in Vivo^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, N.Y.)

Thirty-three known antibiotics were tested for their ability to retard the growth of the Crocker Sarcoma 180 in mice. None is outstandingly effective. Five—namely, actidione, actinomycin, illudin M, illudin S, and terramycin—have slight retarding effects which, with the latter four agents, have been achieved only at doses toxic for the host.

Of more than 1,200 crude antibiotic preparations tested, only five caused sufficient retardation of tumor development to be considered for further work.

^* This work has been supported by an institutional grant from the American Cancer Society.

Received 5/25/53.