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The Action of Cortisone on Transplanted and Induced Tumors in Mice^*

( Division of Oncology, The Chicago Medical School, 2755 West 15th Street, Chicago 8, Ill.)

1. The action of cortisone has been studied on the heterologous transplantation, growth, and metastatic diffusion of a transplantable adenocarcinoma in DBA mice, and on the genesis, growth, and metastatic diffusion of tumors induced in the skin and subcutaneous tissues of Swiss mice with methylcholanthrene.

2. Cortisone did not show any appreciable influence on the heterologous transplantation of a mammary adenocarcinoma from DBA mice and on the growth of methylcholanthrene-induced tumors in Swiss mice.

3. The growth rate of a transplanted adenocarcinoma in DBA mice was temporarily inhibited by the administration of cortisone.

4. The induction of skin tumors in Swiss mice by methylcholanthrene has been markedly inhibited by the administration of 0.5 mg. of cortisone daily.

5. Cortisone has been found to favor an increased metastatic spread of all the experimental tumors studied.

^* This investigation was supported by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 6/20/53.

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