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Partial Reversal of the Antileukemic Activity of A-Methopterin by Cortisone^*

( Biological Laboratory, Southern Research Institute, Birmingham, Ala., Affiliated with Sloan-Kettering Institute)

Data have been presented which indicate that cortisone significantly reduces the antileukemic activity of A-methopterin in two strains of mouse leukemia.

^* This work was supported by a grant from the American Cancer Society, on recommendation by the Committee on Growth of the National Research Council.

Received 9/23/53.