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The Effect of Transplanted and Spontaneous Mouse Mammary Gland Carcinomas on Lymph Nodes^*

( Richard Cohn Radiobiology Laboratory, Detroit Institute of Cancer Research and Wayne University College of Medicine, Detroit, Mich.)

1. The effect of transplanted isologous and homologous tumors and of spontaneous mouse mammary gland carcinomas on the weight, P content of, and the P³² uptake of lymph nodes has been investigated in mice of the C3H/Sp strain.

2. The weight and P³² uptake of the lymph nodes were markedly increased in mice which had received homologous tumor implants over that found in animals bearing either isologous tumor implants or spontaneous tumors or that had been sham-treated with an empty trocar.

3. The uptake of P³² by the lymph nodes was similar in mice that had been sham-treated with an empty trocar, that had received isologous tumor implants, or that bore the larger spontaneous tumors, and was increased over that found in tumor-free, untreated mice.

4. The presence of a spontaneous tumor induced a reticulum-cell hyperplasia in the lymph nodes. This hyperplasia was found not only when the tumor was in close proximity to the node examined, as reported by other workers, but also, when the tumor was distant from the node.

5. Inasmuch as injection of protein fractions from isologous and homologous tumors increased the P³² uptake by lymph nodes to the same degree as the tissue implant, the suggestion is made that the changes in the nodes in tumor-bearing mice are due to the release of antigenic protein from the tumor tissue.

^* Supported in part by grant no. C2151 from the National Cancer Institute of the National Institutes of Health, Public Health Service; and in part by institutional grants to the Detroit Institute of Cancer Research from the American Cancer Society, Inc., American Cancer Society, Southeastern Michigan Division, and the Kresge Foundation.

Received 3/ 1/54.