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Effect of Prolonged Feeding of Methylcholanthrene to Rats Kept on a Low Protein Diet^*

( Department of Pathology, University of Virginia Medical School, Charlottesville, Va.))

Methylcholanthrene at a level of 0.01 per cent was fed to rats in a low protein basic diet over a long period.

In the livers of rats fed the basic diet only, fatty changes and cirrhosis developed; in one rat a cystic cholangioma was found. When rats received MC in their diet, the cirrhosis was more severe, and five rats developed cystic and solid cholangiomas. Male rats were found to be more prone to the development of liver damage than were females.

Ulcers, squamous hyperplasia, and papillomas developed in the stomachs of rats fed the basic diet, as well as in those receiving MC. In the latter group the changes were again more pronounced; one premalignant lesion occurred, and in one case a malignant tumor was present.

^* This investigation was supported by the research grant C 1583 from the National Cancer Institutes of Health, Public Health Service.

Received 6/14/54.