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Time and Site Study for Optimum Lymph Node Concentration of Radiogold Following Intrabronchial Injection^*

Departments of Surgery and Pathology, University of Louisville School of Medicine, Louisville, Ky.

1. Colloidal Au¹⁹⁸ was injected into the bronchial mucosa of dogs in an attempt to determine the rapidity of concentration within the regional lymph nodes and the site of injection for optimum concentration within the nodes.
Specimens of the regional lymph nodes and viscera were measured for radioactivity. Histologic sections and autoradiographs were examined and compared with those from a group of animals receiving a similar dosage of Au¹⁹⁸ and sacrificed in from 1 to 5 weeks.

2. Colloidal radiogold of this particle size concentrated within the regional lymph nodes well within the effective activity range of the isotope. Radioactivity was concentrated in the lymph nodes and was not distributed in any appreciable amount to other organs.

3. The most effective site of injection within the bronchial tree was found to be the most dependent accessible site within the bronchus.

4. Radiation necrosis within the lymph nodes had a patchy distribution when small doses of Au¹⁹⁸ were used. This distribution was confirmed by autoradiographs.

^* This project was supported by a grant from the Damon Runyon Memorial Fund for Cancer Research. The work was done under the supervision of Dr. Marshall Brucer, Chairman of the Medical Division of Oak Ridge Institute of Nuclear Studies. Miss Johanna Meyer contributed technical help and advice.

Received 4/19/54.