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The Effects of Tumor Growth and X-Radiation on the Incorporation of Radiocarbon from 4-Amino-5-imidazolecarboxamide-C¹⁴ into Nucleic Acids^{* ,}

Gaylord M. Conzelman, Jr., H. George Mandel and Paul K. Smith

( Department of Pharmacology, George Washington University School of Medicine, Washington, D.C.)

The incorporation of the purine precursor, 4-amino-5-imidazolecarboxamide, into the nucleic acid purines isolated from the livers of sarcoma-bearing mice was found to be higher than into those of the livers of control mice.

In mice having previously received a total body x-radiation of 400 r, the incorporation of 4-amino-5-imidazolecarboxamide into the PNA purines was higher and into DNA purines was slightly lower than the corresponding values in control mice.

^* This investigation was supported by a contract with the United States Atomic Energy Commission (AT(30-1)-1107), and by research grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service (C-308), and from the Damon Runyan Memorial Fund for Cancer Research, Inc. (DRIR-42C).

This paper forms part of a thesis submitted by Gaylord M. Conzelman, Jr., to the George Washington University, Washington, D.C., in partial fulfilment of the requirements for the degree of Doctor of Philosophy.

Present address: The Christ Hospital, Institute of Medical Research, Cincinnati, Ohio.

Received 9/23/53.