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The Chemistry of Experimental Chloroma

I. Porphyrins and Peroxidases

( Samuel S. Fels Research Institute, Temple University School of Medicine, Philadelphia 40, Pa.)

A porphyrin which appears to be a dicarboxylic acid and which has the solubility and spectrophotometric absorption characteristics of protoporphyrin has been shown to be responsible for at least part of the red fluorescence of experimental chloroma in the rat. Hematin in the chloroma was found in sufficiently low quantities to have originated from occulded blood. A green pigment insoluble in 65–70 per cent alcohol has been isolated from chloroma which is partly soluble in saline, has a high peroxidase activity, and closely resembles verdoperoxidase in its absorption spectrum. Peroxidase activity has been measured in a number of chloromas. These findings have been discussed in the light of the conflicting evidence in the literature regarding the nature and the origin of these pigments.

Received 5/21/53.