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Mutation Rate Following Treatment of Neurospora with 20-Methylcholanthrene and 1,2,5,6-Dibenzanthracene in Tween-80^*

( Department of Surgery, Louisiana State University School of Medicine, New Orleans, La.)

1. Reverse mutation rate at a single gene locus in Neurospora crassa after treatment with 20-methylcholanthrene or 1,2,5,6-dibenzanthracene could be explained more satisfactorily on the basis of selection than a valid increase in mutation frequency.

2. With the use of a technic of direct ascospore isolation, no increase in occurrence of biochemical mutants was found after treatment of Neurospora with 20-methylcholanthrene or 1,2,5,6-dibenzanthracene.

3. Tween-80 is used as a carbon source by Neurospora, and results are profoundly altered when it is used as solvent for carcinogens.

^* Aided by a grant from the National Cancer Institute, Department of Health, Education, and Welfare.

Received 8/12/53.