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Immune Phenomena Elicited by Transplanted Tumors

I. The Participation of the Eye and the Brain^*

( Laboratory Service of the Veterans Administration Hospital, and the Department of Pathology, University of Utah College of Medicine, Salt Lake City, Utah)

Experiments with mouse Sarcoma 37 transplanted heterologously to guinea pigs and with mouse tumor E 0771 transplanted homologously to nonsusceptible mice (Strain A) permit the following conclusions with regard to the isolation of the eye and the brain from systemic immune events:

1. Both the eye and the brain participate in immunity to transplanted heterologous and homologous tumors.

2. This participation is incomplete. There exists a state of relative isolation of these sites, particularly the brain. Not infrequently, a primary inoculation of tumor tissue to eye, brain, or subcutaneous tissue fails to immunize the eye or the brain.

3. Immunization of eye or brain is most effective, in homologous hosts, after subcutaneous inoculation. Subcutaneous inoculation is least effective in heterologous hosts. This apparent contradiction may be explained by the fact that in heterologous hosts subcutaneously inoculated tumors consistently fail to grow and are absorbed in a short period of time, while in most homologous hosts subcutaneous tumors grow sufficiently to cause immunization.

^* Aided by a grant from the USPHS, National Cancer Institute.

Received 9/28/53.