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The Survival and Metastatic Spread of Homografts of Mouse Tumors in Mice Pretreated with Lyophilized Tissue and Cortisone^{* ,}

( Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine)

Homografts of a tumor indigenous to the inbred A strain of mice grew progressively in a large proportion of mice of two C57BL/6 sublines that had received injections of frozen-dried homologous tumor tissue prior to grafting. The homografts often metastasized, metastases appearing only in animals surviving a minimum of 6 weeks after grafting. They were found most frequently in the lungs and kidneys, and also occurred in other sites (various lymph nodes, pancreas, heart, mediastinum). The injection of cortisone along with frozen-dried tumor tissue, prior to grafting, did not affect either the incidence, time of appearance, or distribution of anatomic sites of the metastases.

Intra-abdominal tumor growths, of the type reported by Molomut and co-workers, appeared only in animals receiving intraperitoneal injections of incompletely dried lyophilized tumor tissue in which cells had survived. These growths were present in C57BL/6 mice and in mice of the indigenous A strain that had not received any grafts of fresh tumor. Cortisone injections in mice so treated did not affect the incidence, time of appearance, or nature of the intra-abdominal growths.

^* Supported in part by grants-in-aid from the American Cancer Society, upon recommendation of the Committee on Growth of the National Research Council, and in part by a research grant from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

With the technical assistance of Bradley F. Bryant and Jean L. Harriss.

Received 10/26/53.

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