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Spontaneous Transformation from Carcinomatous to Sarcomatous-like Growth^*

( Cancer Research Laboratory, Department of Hospitals of New York City, and Department of Biology, Graduate School, Washington Square College of New York University, New York, N.Y.)

A spontaneous mouse mammary adenocarcinoma type A which arose in a female mouse of an inbred DBA line retained its original acinar structure during five generations of transfer into DBA mice of this line. The histological pattern of the sixth-generation tumor was that of a mammary adenocarcinoma type B, whereas that of the seventh generation represented a mixed type of tumor, with whorls and bundles of spindle cells and occasional acinar forms. All subsequent generations of this tumor consisted entirely of large spindle-shaped cells with vigorous mitotic activity. The tumor in its present state has proved very useful for experimental purposes.

^* This study was carried out during the tenure of a project which was supported by a grant obtained from the National Cancer Institute, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda, Md.

Received 5/29/53.