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The Inactivation in Vivo of Mouse Lymphosarcoma 6C3HED by Antibodies Produced in a Foreign Host Species^*

( Dept. of Bacteriology, University of Michigan, Ann Arbor, Michigan)

From the results of these experiments, evidence is provided that antibodies can be produced in a foreign host species against a tissue fraction isolated from mouse lymphosarcoma 6C3HED. When this antiserum was used for the in vivo inactivation of the neoplasm, tumors developed in only 18.0 per cent of the sites inoculated with tumor. The injection of tumor-implanted mice with normal rabbit serum resulted in tumor takes in 96.9 per cent of the sites. Attempts to inactivate the tumor with antisera against various mouse tissue pellet fractions resulted in considerably less protection than when the specific antitumor serum was used. Rabbit antisera against a tumor pellet fraction isolated from rat carcinoma tissue were also ineffective (90.4 per cent tumor takes) in protecting mice against tumor development. When the administration of antitumor serum was delayed until 96 hours after tumor implantation or when the antitumor serum was diluted 1:16, no protection was noted.

^* Aided by grants from the Damon Runyon Foundation and the Atomic Energy Commission.

Received 10/22/53.