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A Comparison of the Oxidation of Octanoate-1-C¹⁴, -7-C¹⁴, and Butyrate-1-C¹⁴ by Neoplastic and Normal Mouse Tissues^*

( Department of Physiology, School of Medicine, and the Department of Chemistry of the University of California, Berkeley, Calif.)

1. A study was made of the incorporation of C¹⁴ of octanoate-1-C¹⁴, octanoate-7-C¹⁴, and butyrate-1-C¹⁴ into acetoacetate and CO₂ by (a) slices prepared from normal mouse liver, (b) a cell suspension of a mouse hepatoma, and (c) liver slices of a tumor-bearing mouse. In addition, the acetoacetate derived from these substrates was degraded, and the distribution of the C¹⁴ within the molecule was determined.

2. The distribution of C¹⁴ in the two moieties of acetoacetate, as represented by the C*O:C*OOH ratio, was compatible with the concept of a normal ß-oxidation-cleavage-condensation mechanism in the tumor as well as in the liver and kidney.

^* Aided by a grant from the American Cancer Society as recommended by the Committee on Growth of the National Research Council.

Received 1/11/54.