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The Development of Malignant Tumors of the Face in Rats after Prolonged Treatment with Thiourea

( Department of Experimental Pathology and Cancer Research and the Medical Department "B" of the Hebrew University-Hadassah Medical School, Jerusalem, Israel)

Malignant tumors of the face were observed in five out of six rats treated for more than a year with thiourea. The treatment consisted of intermittent intraperitoneal injections of large doses of thiourea for 6 months followed by continuous administration of 0.2 per cent thiourea in the drinking water. The pathogenesis of the tumors is discussed.

Received 2/ 8/54.