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Elevation of a Serum Component in Neoplastic Disease

( Medical Research Institute, City of Hope Medical Center, Duarte, Calif.; Department of Physiological Chemistry and the Department of Infectious Diseases, School of Medicine, University of California at Los Angeles, Calif.)

1. A procedure has been formulated for the assay of a serum component which catalyzes the oxidation of reduced diphosphopyridine nucleotide and the simultaneous reduction of pyruvic acid to lactic acid.

2. The activity of the sera producing this oxidation-reduction change has been found to be low in healthy individuals and in patients with a number of pathological conditions. It is elevated in neoplastic disease and in pregnancy.

Received 3/27/54.

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