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Further Observations on the Role of the Pituitary and the Adrenal Gland in Azo Dye Carcinogenesis

( Department of Chemistry, Stanford University, Stanford, Calif., and Sloan-Kettering Institute for Cancer Research, Department of Pathology, and Strang Cytology Laboratory, Memorial Center, New York, N.Y.)

1. Male and female hypophysectomized rats were maintained on synthetic diets containing 3'-Me-DAB. Groups of these animals were treated with ACTH, growth hormone, thyrotrophin, pituitary gonadotrophins, and steroid hormones.

2. Hypophysectomized rats are protected against the carcinogenic action of the azo compounds. ACTH partially restored this activity in both sexes. However, the effect appeared less pronounced in females.

3. Growth hormone also restored the activity of the azo dyes in these hypophysectomized animals. Thyrotrophin and gonadotrophin were also active but to a lesser degree than ACTH or growth hormone in restoring this effect. Administration of DOCA to hypophysectomized female rats fed the dye resulted in cirrhosis and bile duct adenomas after 21 weeks in contrast to previous findings with males. Testosterone and Pituitrin were ineffective in restoring this activity.

^* Postdoctorate research fellow, National Cancer Institute, National Institutes of Health.

Received 3/ 8/54.