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The Distribution of Radioactivity Following Administration of Triethylenimino-s-Triazine-C¹⁴ in Tumor-bearing and Control Mice^{* ,}

( Department of Pharmacology, George Washington University School of Medicine, Washington, D.C.)

1. Triethylenimino-1-3-5-triazine-C¹⁴ was synthesized from urea-C¹⁴.

2. A study was made of the excretion and tissue distribution of radioactivity following intraperitoneal administration of TEM-C¹⁴ to control mice and mice bearing Lymphosarcoma 1, Sarcoma 37, or Leukemia 1210.

3. The exhaled carbon dioxide contained little radioactivity. A major portion of the activity was excreted in the urine within 24 hours. The principal radioactive metabolite was identified as cyanuric acid.

4. The uptake of radioactivity by organs of tumor-bearing and control mice 24 hours after injections was low. No striking differences were observed between any of the tumor-bearing groups and the corresponding control groups.

5. There was no selective localization of radioactivity in tumor tissue as compared to other organs.

^* This investigation was carried out during tenure of a Fellowship in Cancer Research of the American Cancer Society, recommended by the Committee on Growth of the National Research Council. The research also was aided by research grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service (c-308), from the Damon Runyon Memorial Fund for Cancer Research, Inc. (DRIR-42D), and by a contract with the United States Atomic Energy Commission (AT(30-1)-1107).

Presented in part at the 44th annual meeting of the American Association for Cancer Research, Chicago, 1953.

Received 3/15/54.