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Tumor Host Relationships

I. Effects on Free Amino Acid Concentrations of Certain Tissues^*

( Department of Physiological Chemistry, University of California School of Medicine, Berkeley, Calif.)

1. The levels of eighteen amino acids have been studied in liver, muscle, and plasma of normal, fasted, and tumor-bearing rats, according to microbiological assay and ion exchange chromatography technics.

2. No pattern of change in the amino acid profile of these tissues was found which was characteristic for the tumor-bearing animal.

3. Those changes in amino acid levels were generally interpreted to be similar to those induced by other states of stress, and may be related to general increased energy demands of the tumor-bearing organism, rather than to specific demands of protein synthesis.

^* Aided by research grants from the American Cancer Society (Institutional Grant No. 43) and the Hobson Fund to the University of California Cancer Research Institute and by the Cancer Research Funds of the University of California.

Received 4/ 5/54.