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The Time Interval between Tumor Inoculation and Metastatic Spread to the Lymph Nodes^*

( Department of Radiology and Pathology, University of Utah Medical School, Salt Lake City, Utah)

Following anterior chamber transplantation of mouse tumor C-1300 into ABC mice, the development of cervical lymph node metastases was observed by various methods. These were eye enucleation, x-ray therapy and observation of cervical lymph node enlargement, transfer of cervical lymph nodes into the flank of susceptible mice, and histologic observation of cervical lymph nodes.

Tumor embolism to nodes occurred as early as the 4th post-transplantation day.

All animals had growing tumors in the cervical nodes by the 12th day after transplantation.

The occurrence of metastases coincides with invasion of the choroid and sclera as demonstrated by serial sections of the eye following transplantation.

^* This study was supported by grants from the James Picker Foundation on recommendation of the Committee on Radiology, National Research Council, and the National Cancer Institute, U.S. Public Health Service.

Received 5/ 3/54.