This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Roberts, S. Search for Related Content PubMed PubMed Citation Articles by Roberts, S.

The Influence of the Adrenal Cortex on Serum Protein Metabolism in Normal and Malignant Lymphoid Tissue^*

( Department of Physiological Chemistry, School of Medicine, University of California Medical Center, Los Angeles 24, Calif.)

Normal lymphoid tissue and a transplantable lymphosarcoma in the rat were found to release to a serum medium in vitro a protein possessing the electrophoretic mobility of serum ß-globulin. In addition, the tumor released appreciable amounts of an "-globulin." Coincidentally, albumin was observed to decline in the serum medium. Similar changes occurred in the blood of rats during the development of the lymphosarcoma following subcutaneous implantation. The rate of release of the "ß-globulin" by both normal and malignant lymphoid tissues seemed to be directly proportional to the level of circulating adrenal cortical steroids. Attention is drawn to the possible relationship between these findings and the growth and regression of the lymphoid tumor under these circumstances.

^* Aided by research grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service, C-1408, and by Cancer Research Funds of the University of California.

Received 5/10/54.