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Studies on the Metabolism of Thioacetamide-S³⁵ in the Intact Rat^*

( Norsk Hydro's Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway)

1. A method for the labeling of thioacetamide (TAA) with radioactive sulfur has been described.

2. When TAA-S³⁵ was injected subcutaneously into rats, more than 80 per cent of the radioactivity was excreted in the urine during the first 24 hours. Approximately 25 per cent was recovered as unaltered TAA, while most of the remainder was accounted for as free and esterified sulfate.

3. Following injection of TAA-S³⁵ the bone marrow, thyroid, and the adrenals of the rat concentrated the compound temporarily to a considerable degree. However, no tissue showed any exceptionally great retention of radioactive sulfur after repeated injections of TAA-S³⁵.

4. The liver, although it is the only organ showing morphological changes after treatment with TAA, did not concentrate TAA-S³⁵ nor retain S³⁵ to any greater extent than the other tissues.

^* This project was supported in part by a grant from Landsforeningen mot Kreft, Oslo, Norway.

Received 4/ 1/54.

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