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Melanoma Chemotherapy

I. Some Properties of Antimelanin Gamma Globulin^*

H. S. Mason, E. W. Peterson, A. Frisch and M. Karens

( Departments of Biochemistry, Dermatology, and Bacteriology, University of Oregon Medical School, and the Radiochemical Laboratory, Reed College, Portland, Ore.)

Antimelanin granule globulins were obtained when the melanin granules from the Harding-Passey mouse melanoma were injected into rabbits in the form of adjuvant mixtures. These antibodies strongly agglutinated suspensions of melanin granules in contrast to sera or gamma globulins from the same animals prior to immunization. No cross agglutinations were obtained with corresponding fractions of liver, lung, heart, aorta, skin, or mouse amelanotic melanoma. The antimelanin granule gamma globulin was tagged with tracer quantities of radioiodine, and its distribution pattern in mice bearing Harding-Passey melanomas was determined. Specific localization in the tumor failed to occur.

^* This study was supported by a grant from the Sloan Foundation, N.Y.

To whom communications concerning this paper should be addressed.

Received 5/ 1/54.