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Attempts to Influence Resistance to the Walker Carcinoma 256 by Administration of Thorium Dioxide (Thorotrast)^*

Louis J. Bernard, Arthur M. Dutton and Michael Radakovich

( Division of Cancer Research, University of Rochester School of Medicine and Dentistry, Rochester, New York)

1. Following strangulation or excision of a primary growth of the Walker carcinoma in Sprague-Dawley rats, there was an enhanced refractoriness to reinoculation of the same tumor. This enhanced refractoriness was effective in preventing growth of a new implant in spite of recurrences from residual primary implants.

2. There was no difference between the incidence of resistance following strangulation of a primary tumor and that following surgical excision. The development of resistance did not depend on absorption of an antigen from the autolyzed tumor.

3. Thorotrast did not increase the incidence of takes of the tumor at a statistically significant level in these experiments.

4. Thorotrast did not affect resistance to second inoculations of tumor following banding of an initial implant.

5. No increased incidence of remote metastases from the secondary tumor was found in animals given Thorotrast before or during the growth period of the primary tumor.

6. No correlation was found between the histology of the lymphoid organs of animals given Thorotrast and the fate of their tumor grafts.

^* This study was supported by a grant from the Anna Fuller Fund.

Public Health Service Research Fellow of the National Cancer Institute.

Statistics Section, Atomic Energy Project.

Received 7/23/54.