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The Effect of Antiphlogistic-corticoid Conditioning (the "A-CC Effect") upon the Walker Tumor^*

( Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal, Canada)

Experiments on intact albino rats have shown that small doses of cortisol, given conjointly with small amounts of ammonium chloride (an "antiphlogistic-corticoid conditioning" substance), failed to influence either the growth or the exudate-forming ability of Walker tumor 256 transplants in the granuloma pouch.

In adrenalectomized rats, treatment with these same substances, at the same dose levels, caused pronounced retardation of tumor growth and inhibition of exudate formation, under otherwise identical conditions.

The experiments suggest that the antineoplastic and anti-exudative effect of cortisol, administered in conjunction with a sensitizing substance such as NH₄Cl, is suppressed by the adrenals, perhaps through the compensatory secretion of a cortisolantagonistic steroid.

^* The experiments reported here were performed with the aid of a grant from the National Cancer Institute of Canada.

Received 7/31/54.