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Induction of Blood-borne Metastases by Tumor Transplantation in the Tail of Mice^*

( Division of Oncology, Chicago Medical School, 2755 West 15th Street, Chicago 8, Ill.)

Tumor Gl-46, a transplantable sarcoma which does not metastasize when implanted into the subcutaneous tissue of the trunk, yielded a high percentage of blood-borne metastases when transplanted into the subcutaneous tissue of the tail. This finding emphasizes the importance of the site of the primary growth in the spread of tumors by blood stream. Its significance and its value as a simple technic for the study of the mechanism of metastases are discussed.

^* This investigation was supported by a research grant from the Damon Runyan Memorial Fund and by a control project grant from the National Cancer Institute, National Institutes of Health, Public Health Service.

Received 8/ 4/54.