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Factors Influencing the Specificity of Action of an Antileukemic Agent (Aminopterin). Multiple Treatment Schedules plus Delayed Administration of Citrovorum Factor

( Laboratory of Chemical Pharmacology and Biometry Section, National Cancer Institute, Bethesda, Md.^*)

Multiple treatment with aminopterin and the administration of CF subsequent to treatment with aminopterin both increase the antileukemic specificity of action of aminopterin in mice. A combination of these treatments was shown to be more effective in this respect than either one alone.

^* National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.

Received 8/ 5/54.