This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Agate, F. J. Articles by Graff, S. Search for Related Content PubMed PubMed Citation Articles by Agate, F. J., Jr. Articles by Graff, S.

The Nonessentiality of the Hypophysis for the Induction of Tumors with 3,4-Benzpyrene^*

( Departments of Anatomy and Biochemistry, Columbia University; and Joseph and Helen Yeamans Levy Foundation, Beth Israel Hospital, New York, N.Y.)

1. Twenty hypophysectomized rats were given injections subcutaneously of a single dose of 3,4-benzpyrene. Twelve intact control rats were similarly treated. All the intact controls developed tumors.

2. Seven hypophysectomized rats died without tumors prior to the 93d day before any of the controls showed tumors. One hypophysectomized animal died without a tumor on the 117th day. The remaining twelve animals all developed tumors between the 106th and the 174th day.

3. Tumors grew at a considerably slower rate in the hypophysectomized animals than in the controls, averaging 28.2 gm. as against an average of 108 gm. in the controls.

4. It is concluded that the hypophysis is nonessential for the production of neoplasms with 3,4-benzpyrene.

^* Aided by a grant from the American Cancer Society.

Some of this material was presented at the annual meeting of the American Association of Anatomists, Galveston, Texas, and published in abstract form in Anat. Rec., 118 (2): 276, 1954.

Received 7/15/54.