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Influence of Gonadectomy and Androgenic Hormone on the Induction of Leukemia by Methylcholanthrene in DBA/2 Mice^*

Arthur Kirschbaum, Annabel G. Liebelt and Nancy Geisse Falls

( Department of Anatomy, Baylor University College of Medicine; Department of Biology, University of Texas M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas; and Department of Anatomy, Univeristy of Illinois College of Medicine, Chicago, Ill.)

1. Gonadectomized mice of either sex were more susceptible than intact DBA/2 mice to the induction of leukemia by methylcholanthrene.

2. Testosterone phenylacetate inhibited methylcholanthrene-induced leukemogenesis in gonadectomized males.

3. Six-month-old DBA/2 mice which resist the leukemogenic action of methylcholanthrene were rendered susceptible by gonadectomy. Gonadectomy did not alter susceptibility of 6-month-old C57BL mice to irradiation-induced leukemogenesis.

^* Supported by grants from the National Cancer Institute, Public Health Service and the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

Present address: Texas Medical Center, Houston, Texas. Work begun at University of Illinois College of Medicine.

Received 7/ 1/55.

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