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The Carcinostatic Activity of Benzylidene Analogs of Puromycin

( American Cyanamid Company, Research Division, Lederle Laboratories, Pearl River, New York)

Fifteen benzylidene analogs of puromycin were shown to be carcinostatic for mammary adenocarcinomas of C3H and C57 mice.

In several prolonged tests, an appreciable incidence of tumor regression was observed.

Received 7/ 5/55.