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The Effect of Tumor Fractions on the Uptake of Carbon-14-Labeled Adenine into the Deoxyribonucleic Acids of Mouse Tissues^*

N. Burr Furlong, E. Jarvis P. Watson, William E. Davis and A. Clark Griffin

( Department of Chemistry, Stanford University, California)

1. C57BL line mice were given injections of homogenates of a transplantable mammary tumor, and the change in adenine-8-C¹⁴ uptake by the deoxyribonucleic acid of several normal tissues was observed.

2. An increase in adenine-8-C¹⁴ uptake into the DNA from liver, spleen, and lung was noted when tumor homogenates were injected.

3. Certain properties of the factor(s) responsible for this increased nucleic acid activity were determined with regard to its behavior toward heat, acid, acetone, and centripetal force.

^* This study was aided by a grant from the American Cancer Society on recommendation of the Committee on Growth of the National Research Council.

1/Lt., U.S. Air Force, Aero Medical Lab., Wright-Patterson Air Force Base, Dayton, Ohio.

Department of Biochemistry, M.D. Anderson Hospital and Tumor Institute, University of Texas, Houston 25, Texas.

Received 2/ 4/55.