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Studies on the Management of Mouse Leukemia (L1210) with Antagonists of Folic Acid^*

( Laboratory of Chemical Pharmacology, and Biometry and Epidemiology Branch, National Cancer Institute, Bethesda, Maryland)

By the employment of appropriate procedures of administration of folic acid antagonists, with or without delayed administration of CF, it was possible, when treatment was initiated several days following implantation, to demonstrate extended survival time of leukemic mice. It was also possible to obtain a significant number of survivors of leukemia. The inoculum level was well above the level which gave 100 per cent takes in untreated animals, and the occurrence of survivors of leukemia apparently resulted from the treatment. Leukemic cells from mice that succumbed after an extensive period of treatment with A-methopterin showed little or no evidence of resistance. The efficacy of treatment on extended multiple treatment schedules, as was formerly observed on limited treatment schedules, appears to be governed primarily by the host-tumor relationship. Factors which may govern this relationship are discussed.

^* Presented in part at the 46th annual meeting of the American Association for Cancer Research, San Francisco, California, April 15–17, 1955.

Received 7/22/55.